All canine diagnoses

Your dog was diagnosed with Uveal Melanoma / Melanocytoma. Most common primary intraocular neoplasm in dogs. 94% affect iris/ciliary body, 6% choroid. Approximately 82% are benign melanocytomas with low metastatic rate (~3.3%). Distinct biology from oral and digital melanoma. Compare 2 treatment options for dogs including Active Monitoring, Enucleation — with survival times, costs, and what to expect during treatment.

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Uveal Melanoma / Melanocytoma

BreedsLabrador RetrieverGerman ShepherdGolden Retriever
canine

Melanocytic

About This Cancer

Uveal melanoma is the most common primary tumour to develop within the eye in dogs, arising from melanocytes in the iris, ciliary body, or choroid — collectively known as the uvea. The biology of uveal melanoma in dogs is notably different from melanoma at other sites: approximately 80% are benign melanocytomas with a very low metastatic rate (about 3%). These benign tumours are typically slow-growing and may be observed for years without intervention, though they can eventually cause secondary problems such as glaucoma (increased eye pressure) or uveitis (inflammation within the eye). When secondary complications arise or the tumour grows rapidly, removal of the eye (enucleation) is typically curative. The key clinical challenge is distinguishing benign from the less common malignant form, which has a higher risk of distant spread.

No validated staging system

Prognostic assessment based on tumour size, growth rate, secondary complications (glaucoma, uveitis), and histological features post-enucleation.

Prognostic Factors(2)
Benign vs malignant histology~82% are benign melanocytomas with excellent prognosis. True malignant uveal melanomas are uncommon but can metastasise.
Secondary complicationsGlaucoma, uveitis, hyphema, or vision loss indicate need for enucleation regardless of tumour biology
Minimum Workup(5 steps)
1Complete ophthalmic examination including fundoscopy
2Ocular ultrasound if intraocular detail obscured
3Thoracic radiographs (staging if malignancy suspected)
4Regional lymph node assessment
5Abdominal ultrasound for staging if malignancy suspected

Median Survival Time Comparison

How long the average patient survives with each treatment

Bar opacity reflects evidence strength
Active Monitoring
See notes
Enucleation
See notes
Reading this page: MST (Median Survival Time) is how long the average patient survives with a given treatment. ORR (Overall Response Rate) is the percentage of patients whose tumour shrank or disappeared. CR = Complete Response (tumour gone); PR = Partial Response (tumour shrank). Hover over any abbreviation for a quick explanation.
Strength of Evidence

Each treatment is rated by how much published research supports its use. Solid bars indicate stronger evidence; dashed bars mean less certainty.

StrongLarge published studies with strong agreement among veterinary oncologists.
ModerateWidely used in clinical practice, but supported by smaller or retrospective studies.
IndirectEvidence comes from a different tumour type or species and has been applied here.
LimitedVery little published data is available for this specific treatment.

Please note: All treatment data is sourced from published peer-reviewed literature. Survival times and cost figures are approximate guides. Your pet's individual factors — including tumour grade, stage, and overall health — will influence outcomes and should guide all treatment decisions. The strength-of-evidence rating reflects how much research exists, not how strongly a treatment is recommended. This tool is designed to help you have informed conversations with your veterinary oncologist, not to replace them. Costs shown are US referral centre estimates and may vary significantly by region.